解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Retinal bipolar cells are essential to the transmission of light information. Although bipolar cell dysfunction can result in blindness, little is known about the factors required for bipolar cell development and functional maturation. The basic helix-loop-helix (bHLH) transcription factor Bhlhb4 was found to be expre...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.08.032
更新日期:2004-09-16 00:00:00
abstract::A longstanding debate in binocular rivalry literature is whether the perceptual competition in rivalry occurs at an early or late stage of visual processing. Central to this debate is the determination of the source of the competition. Overwhelming evidence exists that local interocular differences can lead to binocul...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.08.039
更新日期:2004-09-16 00:00:00
abstract::Activity is known to be important for the refinement of neural connections in the developing brain. In this issue of Neuron, Hanson and Landmesser provide evidence that GABA-dependent spontaneous bursting of motor neurons in the embryonic spinal cord is required for the correct execution of an early axon pathfinding d...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2004.08.027
更新日期:2004-09-02 00:00:00
abstract::Rhythmic spontaneous electrical activity occurs in many parts of the developing nervous system, where it plays essential roles in the refinement of neural connections. By blocking or slowing this bursting activity, via in ovo drug applications at precise developmental periods, we show that such activity is also requir...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.08.018
更新日期:2004-09-02 00:00:00
abstract::RNA transport is an important and fundamental event for local protein synthesis, especially in neurons. RNA is transported as large granules, but little is known about them. Here, we isolated a large RNase-sensitive granule (size: 1000S approximately) as a binding partner of conventional kinesin (KIF5). We identified ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.07.022
更新日期:2004-08-19 00:00:00
abstract::Sexually dimorphic behaviors are likely to involve neural pathways that express the androgen receptor (AR). We have genetically modified the AR locus to visualize dimorphisms in neuronal populations that express AR. Analysis of AR-positive neurons reveals both known dimorphisms in the preoptic area of the hypothalamus...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.07.008
更新日期:2004-08-05 00:00:00
abstract::In this issue of Neuron, Stepanyants et al. embark on quantitative analyses of the axonal and dendritic arbors of cortical neurons. They test whether the paths taken by axons actually bring them closer to their true synaptic partners than they would have gotten by chance encounters based on the same axon trajectories....
journal_title:Neuron
pub_type: 评论
doi:10.1016/j.neuron.2004.07.006
更新日期:2004-07-22 00:00:00
abstract::Brain function relies on specificity of synaptic connectivity patterns among different classes of neurons. Yet, the substrates of specificity in complex neuropil remain largely unknown. We search for imprints of specificity in the layout of axonal and dendritic arbors from the rat neocortex. An analysis of 3D reconstr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.06.013
更新日期:2004-07-22 00:00:00
abstract::The rhodopsin regulatory protein, visual arrestin, undergoes light-dependent trafficking in mammalian and Drosophila photoreceptor cells, though the mechanisms underlying these movements are poorly understood. In Drosophila, the movement of the visual arrestin, Arr2, functions in long-term adaptation and is dependent ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.06.014
更新日期:2004-07-08 00:00:00
abstract::Plus end tracking proteins (+TIPS) bind to microtubules. Results reported by Lee et al. and Zhou et al. in this issue of Neuron demonstrate that, via intracellular pathways signaling to +TIPs, microtubules can be a direct target of guidance cues in steering growth cones and regulating axon elongation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2004.06.009
更新日期:2004-06-24 00:00:00
abstract::The stabilization of learned information into long-term memories requires new gene expression. CREB binding protein (CBP) is a coactivator of transcription that can be independently regulated in neurons. CBP functions both as a platform for recruiting other required components of the transcriptional machinery and as a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.06.002
更新日期:2004-06-24 00:00:00
abstract::K+ channels contain two main functional domains, an ion-selective pore and a sensor that determines whether the cytoplasmic pore gate is open or closed. In this issue of Neuron, Niu et al. provide compelling evidence that the link between sensor and gate is a remarkably simple mechanical spring. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2004.05.017
更新日期:2004-06-10 00:00:00
abstract::Much evidence indicates that prefrontal cortex plays an important role in long-term recognition memory processes. Here, we report primate prefrontal neuronal responses carrying information necessary for long-term visual recognition memory. The responses of many neurons signaled stimulus familiarity even when the perio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.05.013
更新日期:2004-06-10 00:00:00
abstract::G protein-coupled receptors (GPCRs) mediate diverse signaling processes, including olfaction. G protein-coupled receptor kinases (GRKs) are important regulators of G protein signal transduction that specifically phosphorylate activated GPCRs to terminate signaling. Despite previously described roles for GRKs in GPCR s...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00252-1
更新日期:2004-05-27 00:00:00
abstract::In the olfactory bulb of vertebrates or the homologous antennal lobe of insects, odor quality is represented by stereotyped patterns of neuronal activity that are reproducible within and between individuals. Using optical imaging to monitor synaptic activity in the Drosophila antennal lobe, we show here that classical...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00217-x
更新日期:2004-05-13 00:00:00
abstract::Cysteine string protein alpha (CSPalpha)--an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40 chaperones--is thought to regulate Ca2+ channels and/or synaptic vesicle exocytosis. We now show that, in young mice, deletion of CSPalpha does not impair survival and causes no significa...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00190-4
更新日期:2004-04-22 00:00:00
abstract::Human vision adapts to the contrast of patterns by changing its sensitivity, but the origins of this perceptual adaptation have been disputed. In this issue of Neuron, Solomon et al. show that contrast adaptation in the primate arises mostly in the retina for the magnocellular pathway and mostly in the cortex for the ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/s0896-6273(04)00187-4
更新日期:2004-04-08 00:00:00
abstract::Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synaptic plasticity and memory formation. Although significant progress has been made in understanding the role of postsynaptic CaMKII in synaptic plasticity, very little is known about its presynaptic functio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00143-6
更新日期:2004-04-08 00:00:00
abstract::Neurotransmitter receptors are central to communication at synapses. Many components of the machinery for neurotransmission are present prior to synapse formation, suggesting a developmental role. Here, evidence is presented that signaling through glycine receptor alpha2 (GlyRalpha2) and GABA(A) receptors plays a role...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00141-2
更新日期:2004-03-25 00:00:00
abstract::Migraine is a common, disabling, multifactorial, episodic neurovascular disorder of unknown etiology. Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine with aura that is caused by missense mutations in the CACNA1A gene that encodes the alpha(1) subunit of neuronal Ca(v)2.1 Ca(2+) channels....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00085-6
更新日期:2004-03-04 00:00:00
abstract::Acquisition of new learning is challenged by the phenomenon of proactive interference (PI), which occurs when previous learning disrupts later learning. Whereas human neuroimaging studies have focused on the cortical contributions to interference resolution, animal studies demonstrate that efficient resolution of PI d...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00080-7
更新日期:2004-03-04 00:00:00
abstract::Certain neurons in the mammalian brain have long been known to be joined by gap junctions, which are the most common type of electrical synapse. More recently, cloning of neuron-specific connexins, increased capability of visualizing cells within brain tissue, labeling of cell types by transgenic methods, and generati...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(04)00043-1
更新日期:2004-02-19 00:00:00
abstract::To identify the molecular mechanisms underlying psychostimulant-elicited plasticity in the brain reward system, we undertook a phenotype-driven approach using genome-wide microarray profiling of striatal transcripts from three genetic and one pharmacological mouse models of psychostimulant or dopamine supersensitivity...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00048-0
更新日期:2004-02-19 00:00:00
abstract::Synapses have a limited pool of vesicles that are docked and primed for rapid release. In neuroendocrine cells, splice variants of the SNARE protein SNAP-25 and phosphorylation of SNAP-25 independently influence the size of the releasable vesicle pool, possibly by altering the rate of vesicle depriming. Pre- and postt...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/s0896-6273(04)00039-x
更新日期:2004-02-05 00:00:00
abstract::Protein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain elusive. We combined pharmacological manipulations of kinase and phosphatase activities with mutational studies on the exocytotic machinery driving fusion of catecholamine-containing vesicles from chromaffin cells. We found t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00038-8
更新日期:2004-02-05 00:00:00
abstract::Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00874-2
更新日期:2004-01-22 00:00:00
abstract::Since the early days of research into language and the brain, word meaning was assumed to be processed in specific brain regions, which most modern neuroscientists localize to the left temporal lobe. Here we use event-related fMRI to show that action words referring to face, arm, or leg actions (e.g., to lick, pick, o...
journal_title:Neuron
pub_type: 临床试验,杂志文章
doi:10.1016/s0896-6273(03)00838-9
更新日期:2004-01-22 00:00:00
abstract::Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's disease (AD) bring cholesterol to the forefront of AD research. Research from genetics, epidemiology, and cell biology all converge, suggesting that cholesterol plays a central role in the biology of amyloid precursor protein and t...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(03)00840-7
更新日期:2004-01-08 00:00:00
abstract::N-type calcium channels are critical for pain transduction. Inhibitors of these channels are powerful analgesics, but clinical use of current N-type blockers remains limited by undesirable actions in other regions of the nervous system. We now demonstrate that a unique splice isoform of the N-type channel is restricte...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00801-8
更新日期:2004-01-08 00:00:00
abstract::During normal vision, the focus of gaze continually jumps from one important image feature to the next. In this issue of Neuron, Mazer and Gallant analyze neural activity in higher-level visual cortex during this kind of active visual exploration, and they demonstrate a localized enhancement of visual responses that p...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00805-5
更新日期:2003-12-18 00:00:00
abstract::Spontaneous activity patterns in the developing retina appear important for the functional organization of the visual system. We show here that an absence of early retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) is associated with both gain and loss of functional organiz...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00789-x
更新日期:2003-12-18 00:00:00
abstract::The enteric nervous system (ENS) in vertebrates is derived mainly from vagal neural crest cells that enter the foregut and colonize the entire wall of the gastrointestinal tract. Failure to completely colonize the gut results in the absence of enteric ganglia (Hirschsprung's disease). Two signaling systems mediated by...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00730-x
更新日期:2003-12-04 00:00:00
abstract::The role of early visual experience in the establishment of human high-order visual areas is poorly understood. Here we investigated this issue using human amblyopia--a developmental visual disorder, which manifests a central vision (acuity) deficit. Previous fMRI studies of amblyopes have described abnormal functiona...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00720-7
更新日期:2003-12-04 00:00:00
abstract::Clathrin-mediated endocytosis of synaptic vesicles requires molecular rearrangements of proteins as well as lipids. In this issue of Neuron, Schuske et al. and Verstreken et al. show that the lipid-modifying enzyme endophilin recruits and stabilizes the polyphosphoinositide phosphatase synaptojanin at nerve terminals....
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00726-8
更新日期:2003-11-13 00:00:00
abstract::AMPA-type glutamate receptors (AMPARs) play a major role in excitatory synaptic transmission and plasticity. Channel properties are largely dictated by their composition of the four subunits, GluR1-4 (or A-D). Here we show that AMPAR assembly and subunit stoichiometry are determined by RNA editing in the pore loop. We...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00668-8
更新日期:2003-11-13 00:00:00
abstract::Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data f...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(03)00681-0
更新日期:2003-10-30 00:00:00
abstract::To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00682-2
更新日期:2003-10-30 00:00:00
abstract::The entire length of myelinated axons is organized into a series of polarized domains that center around nodes of Ranvier. These domains, which are crucial for normal saltatory conduction, consist of distinct multiprotein complexes of cell adhesion molecules, ion channels, and scaffolding molecules; they also differ i...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(03)00628-7
更新日期:2003-10-09 00:00:00
abstract::I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer subunits are compared to those with linked subunits that force defined stoichiometries. Two strategies that exploit charybd...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00570-1
更新日期:2003-09-25 00:00:00
abstract::The time course and functional significance of the structural changes associated with long-term facilitation of Aplysia sensory to motor neuron synaptic connections in culture were examined by time-lapse confocal imaging of individual sensory neuron varicosities labeled with three different fluorescent markers: the wh...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00595-6
更新日期:2003-09-25 00:00:00